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Current Research

The Effect of a Keto Diet on Alzheimer's Disease using a Paired-Associates Model and the APOE4 Gene

 

Principal Investigator: Dr. Sara Burke

Department: Department of Neuroscience, College of Medicine

Spring 2023 - Current​​​

This project aims to investigate the possibility of a keto diet as a metabolic-based therapy for AD in individuals with the APOE4 gene using a transgenic rat in which the rat APOE gene has been replaced by a human APOE3 or APOE4 gene. Cognitive function will be further analyzed via working memory task performance on touchscreen paradigm and Morris water maze activities.

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My role in this project involves working with our team to safely and accurately run tasks and manage the diets of the rats involved.

Delotterie, David & Mathis, Chantal & Cassel, Jean-Christophe & Dorner, Cornelia & Marti, Anelise. (2014). Optimization of Touchscreen-Based Behavioral Paradigms in Mice: Implications for Building a Battery of Tasks Taxing Learning and Memory Functions. PloS one. 9. e100817. 10.1371/journal.pone.0100817. 

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